ABSTRACT
MicroRNAs are a class of endogenous, non-coding small RNA, 18~24 nucleotides in length, that mediate the post-transcriptional regulation of gene expression. The high conservation, time-dependent and tissue specificity of microRNAs make it possible for forensic body fluid identification, individual age estimation, estimation of postmortem interval, toxicity analysis, and analysis of the cause of death. However, the limitation of the quantity of identified microRNAs and the uncertainty of the research methods also limit the application microRNA in forensic science from theoretical research to practical application.
ABSTRACT
OBJECTIVE To analyze the adverse drug reactions of 6 kinds of quinolones in order to provide information for clinically rational use of drugs.METHODS The adverse drug reactions of quinolones such as norfloxacin,ofloxacin,levofloxacin,ciprofloxacin,fleroxacin and rufloxacin used in outpatients during Feb to May 2007 were collected and retrospectively analyzed.RESULTS The main adverse drug reactions were seen in gastrointestinal system,nervous system,immune system,respiratory system,urinary system etc.From them the symptoms of gastrointestinal system and nervous system were prominent.CONCLUSIONS In use of quinolones it should think highly to their adverse drug reactions.